Cryogenic fuels are fuels that require storage at extremely low temperatures in order to maintain them in a liquid state. These fuels are used in machinery that operates in space (e.g. rockets and satellites) where ordinary fuel cannot be used, due to the very low temperatures often encountered in space, and the absence of an environment that supports combustion (on Earth, oxygen is abundant in the atmosphere, whereas human-explorable space is a vacuum where oxygen is virtually non-existent). Cryogenic fuels most often constitute liquefied gases such as liquid hydrogen.

Some rocket engines use regenerative cooling, the practice of circulating their cryogenic fuel around the nozzles before the fuel is pumped into the combustion chamber and ignited. This arrangement was first suggested by Eugen Sänger in the 1940s. All engines in the Saturn V rocket that sent the first crewed missions to the Moon used this design element, which is still in use today for liquid-fueled engines.

Quite often, liquid oxygen is mistakenly called cryogenic fuel, though it is actually an oxidizer and not fuel - like in any combustion engine, only the non-oxygen component of the combustion is considered "fuel", although this distinction is arbitrary.

Russian aircraft manufacturer Tupolev developed a version of its popular Tu-154 design but with a cryogenic fuel system, designated the Tu-155. Using a fuel referred to as liquefied natural gas (LNG), its first flight was in 1989.